Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs.
Oropharyngeal candidiasis (OPC) is g35 coupe fender the most common human fungal infection, arising typically from T cell immune impairments.IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC.Mice lacking IL-17RA and IL-22RA1 exhibited hig